BACKGROUND:Although the generic drug approval process has a long-term successful track record, concerns remain for approval of narrow therapeutic index generic immunosuppressants, such as tacrolimus, in transplant recipients.Several professional transplant societies and publications have generated skepticism of the generic approval process.Three ma
Differential expression and function of PDE8 and PDE4 in effector T cells: Implications for PDE8 as a drug target in inflammation.
Abolishing the inhibitory signal of intracellular cAMP is a prerequisite for effector T (Teff) cell function.The regulation of cAMP within leukocytes critically depends on its degradation by cyclic nucleotide phosphodiesterases (PDEs).We have previously shown that PDE8A, a PDE isoform with 40-100-fold greater affinity for cAMP than PDE4, is selecti
Administrative contracts and administrative judication process
In this paper, administrative contracts and dispute resolution in administrative contracts are analysed.After a general introduction, the concept and characteristics of administrative contracts are discussed.Also, the regulation of administrative contracts according to the new Croatian administrative procedure law is presented.Then, the solutions o